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JUBLIA (efinaconazole) topical solution, 10%, is specifically formulated to reach the site of onychomycosis, to treat toenail fungus. Follow the steps below to apply JUBLIA with its flow-through brush applicator.

JUBLIA reaches the site of onychomycosis

Below is a helpful video to assist you in the application of JUBLIA. JUBLIA should be applied once daily for 48 weeks, exactly as prescribed by your doctor to help ensure that you get the full benefit of treatment.

Reminder, JUBLIA is applied on, around, and under the nail to get to the site of infection.

How to Apply JUBLIA: A Step-by-Step Guide

Your toenails should be clean and dry before you apply JUBLIA.

  1. Step 1 remove the cap
    Remove the cap from the JUBLIA bottle.
  2. Step 2 squeeze to apply one drop
    Hold the bottle upside down directly over the affected toenail. By turning the bottle upside down, the entire brush will become moistened with the solution.
    Apply one drop of JUBLIA onto the toenail.
    Do not squeeze the bottle, or press or rub the brush firmly against the toenail while applying JUBLIA.
  3. Step 3 apply a second drop
    For the big toenail, also apply a second drop to the end of the toenail using the tip of the brush.
    If needed, repeat Step 2 to re-wet the brush.
  4. Step 4 gently spread JUBLIA
    Use the brush to gently spread JUBLIA around the entire toenail, including the cuticle, folds of the skin next to the sides of the toenail, and underneath the nail.
    Do not squeeze the bottle, or press or rub the brush firmly against the toenail while spreading JUBLIA with the brush.
  5. Repeat Steps 2 to 4 to apply JUBLIA to each affected toenail.
  6. Let JUBLIA dry completely.
  7. After applying JUBLIA to your affected toenails, place the cap on the bottle and screw it on tightly.
  8. Wash your hands with soap and water after applying JUBLIA.

Sticking With Treatment

JUBLIA should be applied once daily for 48 weeks, exactly as directed by your doctor. It may be useful for you to establish a routine to help you stick to your treatment.

Wait for at least 10 minutes after showering, bathing, or washing before applying JUBLIA.

Ask your doctor if JUBLIA is right for you

Useful patient information sheet

Starting treatment?
Get instructions for the best use of JUBLIA.

Useful patient information sheet

Treatment Guide

This document provides information on toenail fungus and on how to use JUBLIA properly to get the most out of treatment.



*This offer is only valid for eligible patients with commercial insurance. Eligible uninsured patients will pay more. This offer is not valid for any person eligible for reimbursement of prescriptions, in whole or in part, by any federal, state, or other governmental programs, including, but not limited to, Medicare (including Medicare Advantage and Part A, B, and D plans), Medicaid, TRICARE, Veterans Administration or Department of Defense health coverage, CHAMPUS, the Puerto Rico Government Health Insurance Plan, or any other federal or state health care programs. This offer is good only in the U.S. at retail pharmacies owned and operated by Walgreen Co. (or its affiliates) or other participating independent retail pharmacies. This offer is not valid in Massachusetts or Minnesota or where otherwise prohibited, taxed or otherwise restricted. Go to for other terms and conditions that apply.


JUBLIA (efinaconazole) topical solution, 10%, is a prescription medicine used to treat fungal infections of the toenails.


  • JUBLIA is for use on nails and surrounding skin only. Do not use JUBLIA in your mouth, eyes, or vagina. Use it exactly as instructed by your doctor.
  • It is not known whether JUBLIA is safe and effective for use in children under 6 years of age.
  • Before you or your child uses JUBLIA, tell your doctor about all medical conditions, including if you are pregnant, are breast feeding, or plan to breastfeed, because it is not known whether JUBLIA can harm an unborn fetus or nursing infant.
  • Tell your doctor about all medications you or your child is taking, and whether you or your child has any other nail infections.
  • JUBLIA is flammable. Avoid heat and flame while applying JUBLIA to your toenail.
  • JUBLIA may cause irritation at the treated site. The most common side effects include: ingrown toenail, redness, itching, swelling, burning or stinging, blisters, and pain. Tell your doctor about any side effects that bother you or do not go away.

To report SUSPECTED ADVERSE REACTIONS, contact Ortho Dermatologics at 1-800-321-4576 or the FDA at 1-800-FDA-1088 or visit

Click here for Prescribing Information, including Patient Information.


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