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JUBLIA (efinaconazole) topical solution, 10%, is specifically formulated to reach the site of onychomycosis to treat toenail fungus. Follow the steps below to apply JUBLIA with its flow-through brush applicator.

JUBLIA reaches the site of onychomycosis

Below is a helpful video to assist you in the application of JUBLIA. JUBLIA should be applied once daily for 48 weeks, exactly as prescribed by your doctor, to help ensure that you get the full benefit of treatment.

Remember, JUBLIA is applied on, around, and under the nail to get to the site of infection. Wait at least 10 minutes after showering, bathing, or washing before applying JUBLIA to ensure your toenails are clean and dry before application.

How to apply JUBLIA: A step-by-step guide

  1. Step 1 remove the cap


    Remove the cap from the JUBLIA bottle.

  2. Step 2 squeeze to apply one drop


    Prepare JUBLIA for application.

    Hold the JUBLIA bottle upside down directly over the affected toenail and gently squeeze the bottle to moisten the entire brush with the solution.

  3. Step 3 apply a second drop


    Apply JUBLIA.
    • While holding the bottle upside down, use the moistened brush to apply JUBLIA by brushing it gently onto the affected toenail(s). Gently squeeze the JUBLIA bottle to moisten the brush if needed.
    • Gently spread JUBLIA over the entire toenail around the cuticle, folds of the skin next to the sides of the toenail, and underneath the end of the toenail.
    • Do not squeeze bottle while spreading JUBLIA. Do not press or rub the brush firmly against the toenail.
  4. Step 4 gently spread JUBLIA


    For the big toenail, repeat Step 3 to apply JUBLIA a second time.

  5. 5

    After applying JUBLIA, the entire toenail and surrounding skin should be covered with the solution. Let the treated area dry completely before covering it with bedding, socks, or other clothing.
  6. 6

    Replace the cap tightly on the bottle.
  7. 7

    Wash your hands with soap and water after applying JUBLIA.

How should I store JUBLIA?

  • Store JUBLIA at room temperature, between 68°F to 77°F (20°C to 25°C). Do not freeze JUBLIA.
  • Keep the bottle tightly closed and store in an upright position.
  • JUBLIA is flammable. Keep away from heat and flame.

Keep JUBLIA and all medicines out of the reach of children.

Sticking with treatment

JUBLIA should be applied once daily for 48 weeks, exactly as directed by your doctor. It may be useful for you to establish a routine to help you stick to your treatment.

  • Use JUBLIA at the same time and place each day (ie, in the morning or before bed)
  • Combine using JUBLIA with other daily activities (ie, after showering*)
  • Set a reminder on your phone or watch
  • When traveling, keep JUBLIA in a convenient place

*Wait for at least 10 minutes after showering, bathing, or washing before applying JUBLIA.

Ask your doctor if JUBLIA is right for you

Helpful patient brochure

Starting treatment?
Get instructions for the best use of JUBLIA.

Treatment Guide

This document provides information on toenail fungus and on how to use JUBLIA properly to get the most out of treatment.

Download Treatment Guide

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JUBLIA® (efinaconazole) topical solution, 10%, is a prescription medicine used to treat fungal infections of the toenails.


  • JUBLIA is for use on nails and surrounding skin only. Do not use JUBLIA in your mouth, eyes, or vagina. Use it exactly as instructed by your doctor.
  • It is not known whether JUBLIA is safe and effective for use in children under 6 years of age.
  • Before you or your child uses JUBLIA, tell your doctor about all medical conditions, including if you are pregnant, are breast feeding, or plan to breastfeed, because it is not known whether JUBLIA can harm an unborn fetus or nursing infant.
  • Tell your doctor about all medications you or your child is taking, and whether you or your child has any other nail infections.
  • JUBLIA is flammable. Avoid heat and flame while applying JUBLIA to your toenail.
  • JUBLIA may cause irritation at the treated site. The most common side effects include: ingrown toenail, redness, itching, swelling, burning or stinging, blisters, and pain. Tell your doctor about any side effects that bother you or do not go away.

To report SUSPECTED ADVERSE REACTIONS, contact Ortho Dermatologics at 1-800-321-4576 or the FDA at 1-800-FDA-1088 or visit

Click here for Prescribing Information, including Patient Information.


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